Dual roles for a tick protein disulfide isomerase during the life cycle of the Lyme disease agent
ABSTRACT The protein disulfide isomerase (PDI) family is a group of enzymes that have thiol-disulfide oxidoreductase, disulfide isomerase, and redox-dependent chaperone activities.PDIs facilitate diverse infections in mammalian hosts by directly binding to pathogens, immunomodulation, or enabling microbial invasion of host cells.PDI homologs within